Acid cleavable PEG-lipids for applications in a ternary gene delivery vectorwz
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چکیده
Highlighting the work of outstanding young scientists at the chemical-and systems-biology interfaces Please take a look at the full table of contents to access the other papers in this issue. A novel class of pH-sensitive PEG lipids bearing acid-cleavable acetal linkages and short PEG chains have been synthesised and used in ternary vector formulations. The cleavage pH was influenced by structural components including the terminal PEG moiety and spacer length.
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Acid cleavable PEG-lipids for applications in a ternary gene delivery vector.
A novel class of pH-sensitive PEG lipids bearing acid-cleavable acetal linkages and short PEG chains have been synthesised and used in ternary vector formulations. The cleavage pH was influenced by structural components including the terminal PEG moiety and spacer length.
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